A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis.
Uropathogenic Escherichia coli (UPEC) deploy an array of virulence factors to successfully establish urinary tract infections.Hemolysin is a tennessee vols boots pore-forming toxin, and its expression correlates with the severity of UPEC infection.Two-component signaling systems (TCSs) are a major mechanism by which bacteria sense environmental cue